ChemicalBook CAS数据库列表 LY310762
LY310762
- CAS号:192927-92-7
- 英文名:LY310762
- 中文名:LY310762
- CBNumber:CB0488147
- 分子式:C24H27O2N2FHCl
- 分子量:0
- MOL File:192927-92-7.mol
LY310762化学性质
- 储存条件 :Sealed in dry,Room Temperature
- 溶解度 :DMSO: 10 mg/mL with heating, soluble
- 形态 :white powder
- 颜色 :White to off-white
- CAS 数据库 :192927-92-7
安全信息
LY310762性质、用途与生产工艺
- 生物活性 LY310762是一种5-HT1D受体拮抗剂，Ki为249 nM，对5-HT1B受体具有较低的亲和力。
- 体外研究 LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40%. LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan.
- 体内研究 Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312±43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases basal levels of 5-HT above vehicle controls, reaching a maximum of 258% compared to the pre-injection control.
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靶点
5-HT 1D Receptor
249 nM (Ki)
LY310762上下游产品信息
上游原料
下游产品
LY310762生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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