ADU-S100 DISODIUM SALT
- CAS号:1638750-95-4
- 英文名:c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS
- 中文名:ADU-S100 DISODIUM SALT
- CBNumber:CB04670984
- 分子式:C20H25N10NaO10P2S2
- 分子量:714.54
- MOL File:1638750-95-4.mol
- 储存条件 :Store at -20°C
- 形态 :Solid
- 颜色 :White to off-white
- 水溶解性 :Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH)
ADU-S100 DISODIUM SALT性质、用途与生产工艺
- 生物活性 ADU-S100 disodium salt (MIW815 disodium salt) 是干扰素基因刺激物的激活剂 (STING),具有有效的抗肿瘤和免疫活性。
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靶点
STING
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体外研究
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
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体内研究
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.
- 更新日期:2024/04/30
- 产品编号:HY-12885A
- 产品名称:ADU-S100 DISODIUM SALT ADU-S100 disodium salt
- CAS编号:1638750-95-4
- 包装:1mg
- 价格:3300元
- 更新日期:2023/03/20
- 产品编号:HY-12885A
- 产品名称:ADU-S100 DISODIUM SALT ADU-S100 disodium salt
- CAS编号:1638750-95-4
- 包装:5mg
- 价格:12000元
- 公司名称:CLEARSYNTH LABS LTD.
- 联系电话:--
- 电子邮件:sales@clearsynth.com
- 国家:印度
- 产品数:6351
- 优势度:58