CD38 inhibitor

CD38 inhibitor 化学性质

沸点 :589.8±50.0 °C(Predicted)
密度 :1.27±0.1 g/cm3(Predicted)
储存条件 :Store at -20°C
溶解度 :DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
形态 :A solid
酸度系数(pKa) :3.17±0.20(Predicted)
颜色 :Light yellow to brown
InChI :InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChIKey :VJQALSOBHVEJQM-QAQDUYKDSA-N
SMILES :N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O

CD38 inhibitor 性质、用途与生产工艺

生物活性 CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553)是一种有效的 CD38 抑制剂，对人CD38和小鼠CD38的IC50分别为7.3 nM和1.9 nM。
靶点
Target Value
mCD38
(Cell-free assay) 1.9 nM
hCD38
(Cell-free assay) 7.3 nM

体内研究

CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle.

Animal Model:	Diet induced obese (DIO) C57Bl6 mice
Dosage:	30 mg/kg
Administration:	Orally once
Result:	NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle.

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