生物活性 靶点 体外研究 体内研究 羰基氰化氯苯腙 试剂级价格
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羰基氰化氯苯腙

羰基氰化氯苯腙,555-60-2,结构式
羰基氰化氯苯腙
  • CAS号:555-60-2
  • 英文名:CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
  • 中文名:羰基氰化氯苯腙
  • CBNumber:CB0421559
  • 分子式:C9H5ClN4
  • 分子量:204.62
  • MOL File:555-60-2.mol
羰基氰化氯苯腙化学性质
  • 熔点 :170-175 °C (dec.)
  • 沸点 :333.84°C (rough estimate)
  • 密度 :1.3807 (rough estimate)
  • 折射率 :1.6110 (estimate)
  • 储存条件 :-20°C
  • 溶解度 :methanol: 10 mg/mL, clear, very deep yellow
  • 形态 :powder
  • 酸度系数(pKa) :6.00±0.10(Predicted)
  • 颜色 :yellow to orange
  • 水溶解性 :Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
  • BRN :1842102
  • 暴露限值 :NIOSH: IDLH 25 mg/m3
  • InChIKey :UGTJLJZQQFGTJD-UHFFFAOYSA-N
  • CAS 数据库 :555-60-2(CAS DataBase Reference)
  • EPA化学物质信息 :Propanedinitrile, [(3-chlorophenyl)hydrazono]- (555-60-2)
安全信息
  • 危险品标志 :T
  • 危险类别码 :23/24/25-36/37/38
  • 安全说明 :26-36/37-45
  • 危险品运输编号 :UN 2811 6.1/PG 3
  • WGK Germany :3
  • RTECS号 :FG5600000
  • TSCA :Yes
  • 危险等级 :6.1
  • 包装类别 :III
  • 海关编码 :29280090

羰基氰化氯苯腙性质、用途与生产工艺

  • 生物活性 CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone)是一种氧化磷酸化抑制剂,是线粒体质子载体解偶联剂,可增加线粒体膜对质子的通透性,从而破坏线粒体膜电位。
  • 靶点

    STING
    IFN-β

  • 体外研究

    CCCP inhibits IFN-β production induced by various types of the STING pathway activators. CCCP suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway. CCCP drastically suppresses the production of IFN-β in DMXAA-treated RAW264.7 cells and MEFs.

  • 体内研究

    The same dosage of 3 mg/kg.bw each of CCCP and PPEF is used. In both the cases 1 log reduction is observed in the bacterial load. However, when 3 mg/kg.bw of PPEF is used in combination with 3 mg/kg.bw of CCCP, 6 log 10 reduction is observed in the bacterial count. The developed model validates the enhanced antibacterial activity of combination therapy. 99m Tc-MIBI signals in the hearts of SD rats administered CCCP (4 mg/kg intraperitoneally) or vehicle is also measured. 99m Tc-MIBI signals decrease in rat hearts administered CCCP, and the ATP content, as measured by 31 P magnetic resonance spectroscopy, decreased simultaneously. To investigate whether CCCP decreased the 99m Tc-MIBI signals in rats, we analyzed the radioisotope activity of excised heart tissue from rats administered CCCP. At 180 min after 99m Tc-MIBI injection, the 99m Tc-MIBI signals from the hearts in the CCCP group are significantly lower than those in the vehicle group.

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羰基氰化氯苯腙 试剂级价格
  • 更新日期:2024/11/11
  • 产品编号:XW55560201
  • 产品名称:羰基氰酯-3-氯苯基腙
  • CAS编号:555-60-2
  • 包装:100MG
  • 价格:83元
  • 更新日期:2024/11/08
  • 产品编号:L06932
  • 产品名称:羰基氰酯-3-氯苯基腙, 98% Carbonyl cyanide 3-chlorophenylhydrazone, 98%
  • CAS编号:555-60-2
  • 包装:100mg
  • 价格:239元
羰基氰化氯苯腙生产厂家
  • 公司名称:Acros Organics
  • 联系电话:--
  • 电子邮件:info@acros.com
  • 国家:比利时
  • 产品数:6772
  • 优势度:81
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