盐酸丁双胍
- CAS号:1190-53-0
- 英文名:BuforMin Hydrochloride
- 中文名:盐酸丁双胍
- CBNumber:CB0407151
- 分子式:C6H16ClN5
- 分子量:193.68
- MOL File:1190-53-0.mol
- 熔点 :177-179?C
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- 形态 :Solid
- 颜色 :White to Off-White
- 稳定性 :Hygroscopic
- CAS 数据库 :1190-53-0
盐酸丁双胍性质、用途与生产工艺
- 生物活性 Buformin hydrochloride (1-Butylbiguanide hydrochloride) 是一种有效的 AMPK 活化剂，也是具有口服活性的双胍类降血糖试剂 (antidiabetic agent)。Buformin 降低肝糖异生并降低血糖生成。Buformin 也具有抗癌活性，可以应用于癌症研究，如宫颈癌、乳腺癌等。
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体外研究
Buformin hydrochloride (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC 50 values of 246.7 μM and 98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively.Buformin hydrochloride (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells.Buformin hydrochloride (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells.
Cell Viability Assay
Cell Line: ErbB-2-overexpressing SKBR3 and BT474 cells Concentration: 0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300 μM, 1, 3, or 10 mM Incubation Time: 5 days Result: Reduced cell viability in erbB-2-overexpressing breast cells. Cell Cycle Analysis
Cell Line: ErbB-2-overexpressing SKBR3 and BT474 cells Concentration: 0.5 mM; 1 mM; 3 mM Incubation Time: 48 hours Result: Increased cells arresting in G0/G1 phase. Western Blot Analysis
Cell Line: ErbB-2-overexpressing SKBR3 and BT474 cells Concentration: 0 mM, 0.1 mM, 0.3 mM, 1 mM, or 3 mM Incubation Time: 24 hours Result: Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner. -
体内研究
Buformin hydrochloride (oral administation; 7.6 mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice.
Animal Model: Female MMTV-erbB-2 transgenic mice Dosage: 7.6 mmol/kg Administration: Oral administation; 7 days Result: Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice. - 类别 有毒物品
- 毒性分级 高毒
- 急性毒性 口服-大鼠 LD50: 320 毫克/公斤; 口服-小鼠 LD50: 380 毫克/公斤
- 可燃性危险特性 热分解排出有毒氮氧化物和氯化氢烟雾
- 储运特性 库房通风低温干燥; 与食品原料类分开存放
- 灭火剂 水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
- 更新日期：2024/11/08
- 产品编号：HY-B2099A
- 产品名称：Buformin hydrochloride
- CAS编号：
- 包装：50 mg
- 价格：800元
- 更新日期：2024/11/08
- 产品编号：HY-B2099A
- 产品名称：盐酸丁双胍 Buformin hydrochloride
- CAS编号：1190-53-0
- 包装：100mg
- 价格：1200元
- 公司名称：TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话：03-36680489
- 电子邮件：Sales-JP@TCIchemicals.com
- 国家：日本
- 产品数：28387
- 优势度：80
- 公司名称：WAKO
- 联系电话：--
- 电子邮件：labchem-tec@wako-chem.co.jp
- 国家：日本
- 产品数：6819
- 优势度：80
