鹅膏氨酸

鹅膏氨酸化学性质

熔点 :141-147 °C
密度 :1.621±0.06 g/cm3 (20 ºC 760 Torr)
储存条件 :Keep in dark place,Inert atmosphere,Room temperature
溶解度 :H2O: soluble1mg/mL, clear, colorless (with sonication)
形态 :White solid
酸度系数(pKa) :2.16±0.10(Predicted)
颜色 :white
气味 (Odor) :Practically odorless. Faint, meat-like, mild and sweet taste in aqueous dilutions.
水溶解性 :Soluble to 10 mM in water and to 100 mM in 1.1eq. NaOH
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
InChIKey :IRJCBFDCFXCWGO-UHFFFAOYSA-N
LogP :-1.070 (est)
CAS 数据库 :2552-55-8(CAS DataBase Reference)

安全信息

鹅膏氨酸性质、用途与生产工艺

生物活性 Ibotenic acid 对 N-甲基-D-天冬氨酸 (NMDA) 和反式-ACPD 或代谢型使君子氨酸 (Qm) 受体位点都具有激动剂活性。
靶点

NMDA receptor
体外研究

Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC ₅₀ =77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media.

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