ASP 7663;ASP-7663;ASP7663
- CAS号:1190217-35-6
- 英文名:ASP7663
- 中文名:ASP 7663;ASP-7663;ASP7663
- CBNumber:CB03959569
- 分子式:C14H14FNO3
- 分子量:263.26
- MOL File:1190217-35-6.mol
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 25 mg/ml,Ethanol: 25 mg/ml
- 形态 :A crystalline solid
- 颜色 :Light yellow to orange
ASP 7663;ASP-7663;ASP7663性质、用途与生产工艺
- 生物活性 ASP7663 是具有口服活性的、选择性的 TRPA1 激动剂。ASP7663 具有抗便秘和抗腹痛的活性。
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体外研究
ASP7663 concentration dependently increases intracellular Ca 2+ concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC 50 values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L.
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体内研究
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice.
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide.
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat.
Animal Model: CRD model (colorectal distension in rat). Dosage: 1 and 3 mg/kg. Administration: Orally. Result: Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.
- 更新日期：2025/02/08
- 产品编号：HY-101907
- 产品名称：ASP7663
- CAS编号：1190217-35-6
- 包装：1 mg
- 价格：419元
- 更新日期：2025/02/08
- 产品编号：HY-101907
- 产品名称：ASP 7663;ASP-7663;ASP7663 ASP7663
- CAS编号：1190217-35-6
- 包装：5mg
- 价格：1000元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
