棉花素
- CAS号:489-35-0
- 英文名:GOSSYPETIN
- 中文名:棉花素
- CBNumber:CB0373362
- 分子式:C15H10O8
- 分子量:318.24
- MOL File:489-35-0.mol
- 熔点 :302-304°C
- 沸点 :679.3±55.0 °C(Predicted)
- 密度 :1.912
- 储存条件 :Hygroscopic, Refrigerator, under inert atmosphere
- 溶解度 :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated))
- 酸度系数(pKa) :6.47±0.40(Predicted)
- 形态 :Solid
- 颜色 :Dark Yellow
- LogP :1.160 (est)
棉花素性质、用途与生产工艺
- 生物活性 Gossypetin 是六羟基化的类黄酮，是一种有效的 MKK3 和 MKK6 抑制剂，可强烈减弱 MKK3/6-p38 信号传导途径，具有多种药理活性，包括抗氧化，抗菌和抗癌活性。
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靶点
p38 MAP kinase
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体外研究
Gossypetin (20-60 μM; 48 hours; KYSE30, KYSE450 and KYSE510 cells) treatment significantly inhibits anchorage-dependent esophageal cancer cell growth in dose dependent manner. Gossypetin strongly suppresses anchorage-independent cell growth in esophageal cancer cells.
Gossypetin (60 μM; 3 hours; KYSE30 and KYSE410 cells) treatment strongly inhibits p38 activity in a dose-dependent manner and confirms that Gossypetin directly suppresses MKK3 or MKK6 activity.
Gossypetin (20-40 μM; 48 hours; KYSE450 and KYSE510 cells) treatment reduces S phase and induces G2 phase cell cycle arrest in a dose-dependent manner.
Gossypetin (20-40 μM; 72 hours; esophageal cancer cells) treatment induces intrinsic apoptosis of esophageal cancer cells.Cell Proliferation Assay
Cell Line: KYSE30, KYSE450 and KYSE510 cells Concentration: 20 μM, 40 μM, 60 μM Incubation Time: 48 hours Result: Anchorage-dependent esophageal cancer cell growth was significantly inhibited. Western Blot Analysis
Cell Line: KYSE30 and KYSE410 ccells Concentration: 60 μM Incubation Time: 3 hours Result: p38 activity was strongly inhibited in a dose-dependent manner. Cell Cycle Analysis
Cell Line: KYSE450 and KYSE510 cells Concentration: 20 μM, 40 μM Incubation Time: 48 hours Result: Reduced S phase and induces G2 phase cell cycle arrest in a dose-dependent manner. Apoptosis Analysis
Cell Line: Esophageal cancer cells Concentration: 20 μM, 40 μM Incubation Time: 72 hours Result: Induced apoptosis of esophageal cancer cells. -
体内研究
Gossypetin (100 mg/kg; oral administration; 5 times per week; for 21 days; severe combined immunodeficiency (SCID) female mice) treatment significantly decreases the volume of esophageal tumor growth and without significant loss of body weight. The expression of Ki67 is significantly decreased by Gossypetin. There are no obvious morphological differences between tissues from treated or untreated mic. The phosphorylation of p38, the direct downstream protein of MKK3/6 strongly inhibited in the Gossypetin-treated group.
Animal Model: Severe combined immunodeficiency (SCID) female mice (6-9 weeks old) injection with esophageal cancer tissue Dosage: 100 mg/kg Administration: Oral administration; 5 times per week; for 21 days Result: Suppressed patient-derived esophageal xenograft tumor growth in an in vivo mouse model.
- 更新日期：2025/02/08
- 产品编号：HY-119917
- 产品名称：棉花素 Gossypetin
- CAS编号：489-35-0
- 包装：1mg
- 价格：2700元
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
- 公司名称：ABCR
- 联系电话：--
- 电子邮件：info@abcr.de
- 国家：德国
- 产品数：6831
- 优势度：75
