DSR 6434
- CAS号:1059070-10-8
- 英文名:DSR 6434
- 中文名:DSR 6434
- CBNumber:CB03310328
- 分子式:C19H28N8O2
- 分子量:400.48
- MOL File:1059070-10-8.mol
- 密度 :1.283±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO:145.03(Max Conc. mg/mL);362.12(Max Conc. mM)
- 形态 :A solid
- 酸度系数(pKa) :10.22±0.20(Predicted)
- 颜色 :Light yellow to yellow
DSR 6434性质、用途与生产工艺
- 生物活性 DSR-6434 是一种有效的选择性的 Toll 样受体 7 (TLR7) 激动剂，对人和小鼠 TLR7 的 EC50 分别为 7.2 nM 和 4.6 nM。DSR-6434 具有很强的抗肿瘤作用。
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靶点
TLR7
7.2 nM (EC 50 , Human)
TLR7
4.6 nM (EC 50 , Mice)
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体外研究
To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. DSR-6434 is capable of stimulating reporter gene activity only in HEK293 cells expressing hTLR7 and not in HEK293 cells expressing the structurally similar hTLR8 or hTLR9.
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体内研究
DSR-6434 treatment (Compound 20; 0.1-1 mg/kg; intravenous injection; biweekly; for 4 weeks; B6C3F1 mice) suppresses the lung metastasis significantly, 78% inhibition at 0.1 mg/kg dosing (with no tumor metastasis at the 1 mg/kg group).
Animal Model: B6C3F1 mice injected with HM-1 ovarian cancer cells Dosage: 0.1 mg/kg, 1 mg/kg Administration: Intravenous injection; biweekly; for 4 weeks Result: Suppressed the lung metastasis significantly, 78% inhibition was seen at 0.1 mg/kg dosing (with no tumor metastasis at the 1 mg/kg group).
- 更新日期：2024/11/08
- 产品编号：HY-110120
- 产品名称：DSR-6434
- CAS编号：
- 包装：1 mg
- 价格：495元
- 更新日期：2024/11/08
- 产品编号：HY-110120
- 产品名称：DSR 6434 DSR-6434
- CAS编号：1059070-10-8
- 包装：5mg
- 价格：1300元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
