ChemicalBook CAS数据库列表 36840-10-5
36840-10-5
- CAS号:36840-10-5
- 英文名:4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
- 中文名:36840-10-5
- CBNumber:CB03172261
- 分子式:C20H16N2O6
- 分子量:380.35
- MOL File:36840-10-5.mol
36840-10-5化学性质
- 沸点 :758.0±60.0 °C(Predicted)
- 密度 :1.444±0.06 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: 83.33 mg/mL (219.09 mM)
- 酸度系数(pKa) :3.16±0.10(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to yellow
36840-10-5性质、用途与生产工艺
- 生物活性 LPA2 antagonist 2 是一种选择性 LPA2 拮抗剂，IC50 为 28.3 nM，Ki 为 21.1 nM，比 LPA3 (IC50 为 13.85 μM) 选择性高 480 倍以上。
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靶点
IC50: 28.3 nM (LPA 2 ); 13.85 μM (LPA 3 )
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体外研究
Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA 1 with an Imax of 59.0% at 30 µM.
36840-10-5上下游产品信息
上游原料
下游产品
36840-10-5生产厂家
- 公司名称：Fluorochem Ltd
- 联系电话：--
- 电子邮件：vernam@fluorochem.co.uk
- 国家：英国
- 产品数：6375
- 优势度：65
