生物活性 体外研究 体内研究 VX-787 试剂级价格
ChemicalBook  CAS数据库列表  VX-787

VX-787

VX-787,1629869-44-8,结构式
VX-787
  • CAS号:1629869-44-8
  • 英文名:Pimodivir
  • 中文名:VX-787
  • CBNumber:CB03169595
  • 分子式:C20H19F2N5O2
  • 分子量:399.39
  • MOL File:1629869-44-8.mol
VX-787化学性质
  • 密度 :1.501±0.06 g/cm3(Predicted)
  • 储存条件 :Store at -20°C
  • 溶解度 :Soluble in DMSO, not in water:100.0(Max Conc. mg/mL);250.38(Max Conc. mM)
  • 形态 :A solid
  • 酸度系数(pKa) :4.32±0.40(Predicted)
  • 颜色 :White to light yellow

VX-787性质、用途与生产工艺

  • 生物活性 Pimodivir (VX-787) 是一种可口服的甲型流感病毒聚合酶抑制剂,通过抑制PB2亚基起作用。
  • 体外研究

    Pimodivir rescues macrophages from virus-mediated death at non-cytotoxic concentrations 24 hpi. The EC 50 value for Pimodivir are 8 and 12 nM for A(H1N1) and A(H3N2) strains, respectively, whereas the CC 50 values are >1 μM, giving selectivity indexes (SI) > 125 and > 83 for A(H1N1) and A(H3N2) strains, respectively. Pimodivir significantly attenuates the transcription of viral M1 RNA in macrophages, which are infected with A(H1N1) or A(H3N2) strains for 8 h. Pimodivir inhibits the transcription of viral but not cellular genes. Pimodivir allows some activation of IAV-mediated expression of several cellular genes, which are involved in tryptophan and nucleotide metabolism. Pimodivir possesses excellent anti-IAV but not immuno/metabolo-modulating effect. Pimodivir (VX-787) is very potent against influenza A strains, including pandemic 2009 H1N1 and avian H5N1. Pimodivir (VX-787) shows potent activity against all influenza A virus strains tested, with an EC 50 range of 0.13 to 3.2 nM. Pimodivir-selected PB2 variant viruses maintain susceptibility to neuraminidase inhibitors in vitro.

  • 体内研究

    Pimodivir (2, 6, and 20 mg/kg/day, p.o.) and GS 4071 (20 mg/kg/day) completely prevent death in the H1N1pdm virus infection in mice. Pimodivir (20 mg/kg/day) is more effective than GS 4071 (20 mg/kg/day) in improving body weight and reducing the severity of lung infection. Moreover, Pimodivir (VX-787) shows 100% survival in a +48 h delay to treatment mouse influenza model at 10, 3 and 1 mpk (BID × 10 days) whereas the SOC, GS 4071, provide no survival benefit in this model at 10 mpk. Pimodivir (VX-787; 1, 3, or 10 mg/kg, bid) provided complete survival, with a dose-dependent reduction in BW loss of the mice.

VX-787上下游产品信息
上游原料
下游产品
VX-787 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-12353A
  • 产品名称:VX-787 Pimodivir
  • CAS编号:1629869-44-8
  • 包装:5mg
  • 价格:900元
  • 更新日期:2024/11/08
  • 产品编号:HY-12353A
  • 产品名称:VX-787 Pimodivir
  • CAS编号:1629869-44-8
  • 包装:10mM * 1mLin DMSO
  • 价格:990元
VX-787生产厂家
  • 公司名称:TargetMol Chemicals Inc.
  • 联系电话:+1-781-999-5354 +1-00000000000
  • 电子邮件:marketing@targetmol.com
  • 国家:美国
  • 产品数:32161
  • 优势度:58
  • 公司名称:InvivoChem
  • 联系电话:+1-708-310-1919 +1-13798911105
  • 电子邮件:sales@invivochem.cn
  • 国家:美国
  • 产品数:6391
  • 优势度:58
  • 公司名称:Cckinase, Inc.
  • 联系电话:+1 (732)236-3202
  • 电子邮件:sales@cckinase.com
  • 国家:美国
  • 产品数:2738
  • 优势度:58
  • 公司名称:TargetMol Chemicals Inc.
  • 联系电话:
  • 电子邮件:support@targetmol.com
  • 国家:美国
  • 产品数:38631
  • 优势度:58
  • 公司名称:CAYMAN
  • 联系电话:--
  • 电子邮件:cayman@caymanchem.com
  • 国家:美国
  • 产品数:6213
  • 优势度:81
  • 公司名称:United States Biological Inc.
  • 联系电话:--
  • 电子邮件:chemicals@usbio.net
  • 国家:美国
  • 产品数:6214
  • 优势度:80
  • 公司名称:MedChemExpress
  • 联系电话:--
  • 电子邮件:sales@medchemexpress.com
  • 国家:美国
  • 产品数:6398
  • 优势度:58
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