ChemicalBook CAS数据库列表 MELFLUFEN HYDROCHLORIDE
MELFLUFEN HYDROCHLORIDE
- CAS号:380449-54-7
- 英文名:Nelotanserin
- 中文名:MELFLUFEN HYDROCHLORIDE
- CBNumber:CB03159936
- 分子式:C24H31Cl3FN3O3
- 分子量:534.88
- MOL File:380449-54-7.mol
MELFLUFEN HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 Melflufen (Melphalan flufenamide) hydrochloride，Melphalan 的一种二肽前体药物，是一种烷基化剂。Melflufen hydrochloride 对多发性骨髓瘤细胞具有抗肿瘤活性，并抑制血管生成。Melflufen hydrochloride 对骨髓瘤细胞 DNA 不可逆损伤及细胞毒作用。
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体外研究
Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner.
Melflufen hydrochloride induces apoptosis in MM.1S cells.
Melflufen hydrochloride also is a potent activator of exosome secretion.
Cell Viability Assay
Cell Line: Multiple myeloma cells: MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6 cells Concentration: 0.5, 1, 3, 5, 10 μM Incubation Time: 24 hours Result: A significant concentration-dependent decrease in viability of all cell lines was observed. -
体内研究
Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.
Animal Model: CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model) Dosage: 3 mg/kg Administration: 1.v.; twice-weekly for two weeks Result: Significantly inhibited MM tumor growth and prolonged survival of mice.
MELFLUFEN HYDROCHLORIDE上下游产品信息
上游原料
下游产品
MELFLUFEN HYDROCHLORIDE 试剂级价格
- 更新日期：2024/04/30
- 产品编号：HY-105019A
- 产品名称：Melflufen hydrochloride
- CAS编号：
- 包装：1 mg
- 价格：1909元
- 更新日期：2024/04/30
- 产品编号：HY-105019A
- 产品名称：MELFLUFEN HYDROCHLORIDE Melflufen hydrochloride
- CAS编号：380449-54-7
- 包装：5mg
- 价格：4200元
MELFLUFEN HYDROCHLORIDE生产厂家
- 公司名称：Aladdin Scientific
- 联系电话：+1-+1(833)-552-7181
- 电子邮件：sales@aladdinsci.com
- 国家：美国
- 产品数：52927
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
