生物活性 靶点 体外研究 Apcin 试剂级价格
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Apcin

Apcin,300815-04-7,结构式
Apcin
  • CAS号:300815-04-7
  • 英文名:Apcin
  • 中文名:Apcin
  • CBNumber:CB03067532
  • 分子式:C13H14Cl3N7O4
  • 分子量:438.65
  • MOL File:300815-04-7.mol
Apcin化学性质
  • 密度 :1.68±0.1 g/cm3(Predicted)
  • 储存条件 :room temp
  • 溶解度 :DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
  • 酸度系数(pKa) :9.67±0.46(Predicted)
  • 形态 :powder
  • 颜色 :white to beige

Apcin性质、用途与生产工艺

  • 生物活性 Apcin (APC inhibitor) 是一种有丝分裂的 anaphase-promoting complex/cyclosome (APC/C) 的E3连接酶活性的抑制剂,其可与Cdc20结合并竞争性地抑制含D-box底物的泛素化。
  • 靶点
    TargetValue
    APC/C
    ()
    CDC20
    ()
  • 体外研究

    Apcin (25-50 μM; 48 hours) significantly increases MM apoptosis combining with proTAME (6, 12 μM).
    Apcin (25 μM; 2-14 hours) induces slippage more slowly.
    Apcin (50-200 μM) stabilizes cycB1-NT and securin most effectively, with somewhat weaker effects against full-length cyclin B1.
    Apcin (1.5-200 μM; 18 hours) synergizes with proTAME (a cell-permeable TAME prodrug) to prolong mitotic duration in RPE1 cells.

    Apoptosis Analysis

    Cell Line: HMCLs LP-1 and RPMI-8226 cells
    Concentration: 25, 50 μM
    Incubation Time: 48 hours
    Result: Had minor effects on multiple myeloma (MM) cells alone and significantly increased MM apoptosis combining with proTAME (6, 12 μM).

    Western Blot Analysis

    Cell Line: HeLa cells with Nocodazole (100 nM)
    Concentration: 25 μM
    Incubation Time: 2-14 hours
    Result: Induced slippage more slowly, as indicated by Cdc27 dephosphorylation and a reduction in cyclin B1, securin and phosphoH3 levels beginning 4-6h after mitotic entry.
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Apcin 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-110287
  • 产品名称:Apcin
  • CAS编号:
  • 包装:1 mg
  • 价格:419元
  • 更新日期:2024/11/08
  • 产品编号:HY-110287
  • 产品名称:Apcin Apcin
  • CAS编号:300815-04-7
  • 包装:5mg
  • 价格:1000元
Apcin生产厂家
  • 公司名称:上海超岚化工科技中心
  • 联系电话:021-QQ:65489617 15618227136
  • 电子邮件:Sales@ATKchemical.com
  • 国家:中国
  • 产品数:7295
  • 优势度:58
  • 公司名称:北京索莱宝科技有限公司
  • 联系电话:010-50973130 4009686088
  • 电子邮件:3193328036@qq.com
  • 国家:中国
  • 产品数:29785
  • 优势度:68