1177501-39-1
- CAS号:1177501-39-1
- 英文名:FelbaMate (hydrate)
- 中文名:1177501-39-1
- CBNumber:CB02681999
- 分子式:C11H16N2O5
- 分子量:256.26
- MOL File:1177501-39-1.mol
- 储存条件 :Store at -20°C
- 溶解度 :Soluble in DMSO
- 形态 :Powder
1177501-39-1性质、用途与生产工艺
- 生物活性 Felbamate hydrate (W-554 hydrate) 是非镇静性抗痉挛剂,活性与NMDA受体相关。
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靶点
NMDA Receptor.
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体外研究
Felbamate hydrate (W-554 hydrate) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy. Felbamate (W-554) has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.
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