1,3-二咖啡酰奎宁酸

用途生物活性靶点体外研究体内研究 1,3-二咖啡酰奎宁酸试剂级价格

1,3-二咖啡酰奎宁酸

CAS号:19870-46-3
英文名:CYNARIN
中文名:1,3-二咖啡酰奎宁酸
CBNumber:CB02457303
分子式:C25H24O12
分子量:516.45
MOL File:19870-46-3.mol

1,3-二咖啡酰奎宁酸化学性质

沸点 :819.9±65.0 °C(Predicted)
密度 :1?+-.0.1 g/cm3(Predicted)
储存条件 :Keep in dark place,Sealed in dry,2-8°C
溶解度 :soluble5mg/mL, clear, colorless to light yellow
形态 :Solid
酸度系数(pKa) :2.50±0.50(Predicted)
颜色 :white to off-white
稳定性 :Hygroscopic

安全信息

WGK Germany :3

1,3-二咖啡酰奎宁酸性质、用途与生产工艺

用途
1,3-二咖啡酰奎宁酸是一种抗高脂血症的药物。此外，作为神经保护剂对抗淀粉样蛋白-β毒性治疗阿尔茨海默病。
生物活性 1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物，具有抗氧化活性和自由基清除活性。
靶点

Akt

PI3K
体外研究

1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons. 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A). 1,3-Dicaffeoylquinic acid's anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax. 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.
体内研究

1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.
化学性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于洋蓟叶，朝鲜蓟，森林千里光全草、金银花。
用途 1,5-O-二咖啡酰奎宁酸具有护肝，降低胆醇的作用。
用途用于含量测定/鉴定/药理实验等。
药理药效:具有氧化、抗炎、抗病毒、抗纤维化、抑制平滑肌收缩、降血脂等诸多作用。