尿苷5'-三磷酸酯
- CAS号:63-39-8
- 英文名:UTP
- 中文名:尿苷5'-三磷酸酯
- CBNumber:CB0221667
- 分子式:C9H15N2O15P3
- 分子量:484.14
- MOL File:63-39-8.mol
- 密度 :2.106±0.06 g/cm3(Predicted)
- 闪点 :113 °C
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :Easily soluble (water)
- 形态 :liquid
- 酸度系数(pKa) :pK1:7.58 (25°C)
- 颜色 :colorless
- 水溶解性 :Water : ≥ 150 mg/mL (309.83 mM)
- CAS 数据库 :63-39-8(CAS DataBase Reference)
- EPA化学物质信息 :Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)
- 危险品标志 :Xn
- 危险类别码 :20/21/22-68/20/21/22
- 安全说明 :22-26-36
- WGK Germany :1
尿苷5'-三磷酸酯性质、用途与生产工艺
- 生物活性 Uridine triphosphate (UTP;Uridine 5'-triphosphate) 是一种核苷酸，在正常和疾病状态时，调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。
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靶点
Human Endogenous Metabolite
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体外研究
Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.
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体内研究
Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes.
- 更新日期：2024/11/11
- 产品编号：XW6339802
- 产品名称：试剂Uridine triphosphate Uridine triphosphate
- CAS编号：
- 包装：50mg
- 价格：878元
- 更新日期：2024/11/11
- 产品编号：XW6339801
- 产品名称：试剂Uridine triphosphate Uridine triphosphate
- CAS编号：
- 包装：10mg
- 价格：372元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
