R(+)-3-氨基-1-羟基-2-吡咯烷酮

生物活性靶点体内研究 R(+)-3-氨基-1-羟基-2-吡咯烷酮试剂级价格

CAS号:123931-04-4
英文名:(R)-(+)-HA-966
中文名:R(+)-3-氨基-1-羟基-2-吡咯烷酮
CBNumber:CB0190556
分子式:C4H8N2O2
分子量:116.12
MOL File:123931-04-4.mol

R(+)-3-氨基-1-羟基-2-吡咯烷酮化学性质

熔点 :166℃
沸点 :258.6±50.0 °C(Predicted)
密度 :1.436±0.06 g/cm3(Predicted)
储存条件 :Desiccate at RT
溶解度 :H₂O: soluble
酸度系数(pKa) :7.19±0.20(Predicted)
形态 :solid
颜色 :white
旋光性 (optical activity) :[α]22/D +103°, c = 1 in H2O(lit.)
水溶解性 :Soluble to 100 mM in water

安全信息

WGK Germany :3

R(+)-3-氨基-1-羟基-2-吡咯烷酮性质、用途与生产工艺

生物活性 (R)-(+)-HA-966 ((+)-HA-966) 是 N-甲基-D-天冬氨酸 (NMDA) 受体复合物的甘氨酸位点的部分激动剂/拮抗剂。(R)-(+)-HA-966 通过苯丙胺选择性阻断中脑边缘多巴胺系统的活化。(R)-(+)-HA-966 可透过血脑屏障，有用于神经性和急性疼痛的潜力。
靶点

glycine site of the NMDA receptor

体内研究

(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.).
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g).

Animal Model:	Sprague-Dawley rats (11 to 12 weeks old)
Dosage:	10 mg/kg
Administration:	IV
Result:	Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.