SR 33805

生物活性靶点体外研究体内研究 SR 33805 试剂级价格

SR 33805

CAS号:121345-64-0
英文名:SR 33805
中文名:SR 33805
CBNumber:CB01400869
分子式:C32H40N2O5S
分子量:564.7354
MOL File:121345-64-0.mol

SR 33805化学性质

储存条件 :Store at -20°C

SR 33805性质、用途与生产工艺

生物活性 SR33805 是一种有效的 Ca2+ 通道拮抗剂，在去极化和极化条件下的 EC50 值分别为 4.1 nM 和 33 nM。SR33805 阻止 L 型而不是 T 型 Ca2+ 通道。SR33805 可用于研究急性或慢性心脏衰竭。

靶点

L-type calcium channel

4.1 nM (EC ₅₀ , in depolarized conditions)

L-type calcium channel

33 nM (EC ₅₀ , in polarized conditions)

体外研究

SR33805 (0.01-10 µM; 3 d) inhibits growth factor-induced proliferation of SMC (0.20 50<0.46 µM) in a dose-dependent manner.
SR33805 (10 µM; 10 min) restores the myocardial infarction (MI)-altered cell shortening without affecting the Ca ²⁺ transient amplitude.
SR33805 (10 µM) decreases the activity of recombinant PKA.

Cell Viability Assay

Cell Line:	Smooth muscle cells (SMC)
Concentration:	0.01, 0.1, 1, 10 µM
Incubation Time:	3 days
Result:	Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC ₅₀ s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 µM, respectively.

体内研究

SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats.
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs.

Animal Model:	Male Wistar rats (5 weeks) are subjected to coronary artery ligature
Dosage:	0.2, 2, 20 mg/kg
Administration:	A single i.p. injection
Result:	Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg. Did not affect other contractile parameters.