ChemicalBook CAS数据库列表 外消旋-莫地帕泛
外消旋-莫地帕泛
- CAS号:122956-68-7
- 英文名:modipafant
- 中文名:外消旋-莫地帕泛
- CBNumber:CB01310883
- 分子式:C34H29ClN6O3
- 分子量:605.09
- MOL File:122956-68-7.mol
外消旋-莫地帕泛化学性质
- 密度 :1.34±0.1 g/cm3 (20 ºC 760 Torr)
- 储存条件 :Store at -20°C
- 酸度系数(pKa) :12.14±0.70(Predicted)
- 形态 :Solid
- 颜色 :Light yellow to yellow
外消旋-莫地帕泛性质、用途与生产工艺
- 生物活性 (Rac)-Modipafant (UK-74505) 是一种口服的、选择性的、长效的不可逆血小板活化因子受体 (PAFR) 受体拮抗剂。(Rac)-Modipafant 预防严重登革热感染。
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体内研究
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC 50 =26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.Animal Model: 8- to 10-week-old BALB/c mice (DEN-2 strain infected) Dosage: 10 mg/kg Administration: P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 Result: Decreased by approximately 50% the lethality associated with DEN-2 infection. Animal Model: Male BALB/C (8- to 10- week-old) wild-type mice Dosage: 5, 10 and 20 mg/kg Administration: P.o. Result: Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
外消旋-莫地帕泛上下游产品信息
上游原料
下游产品
外消旋-莫地帕泛 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-108908
- 产品名称：(Rac)-Modipafant
- CAS编号：
- 包装：1 mg
- 价格：3400元
- 更新日期：2024/08/19
- 产品编号：HY-108908
- 产品名称：外消旋-莫地帕泛 (Rac)-Modipafant
- CAS编号：122956-68-7
- 包装：5 mg
- 价格：8500元
外消旋-莫地帕泛生产厂家
- 公司名称：CHEMICAL LAND21
- 联系电话：--
- 电子邮件：sales21@chemicalland21.com
- 国家：韩国
- 产品数：6303
- 优势度：74
