甲醇中甲氧酩胺溶液标准物质
- CAS号:1477-68-5
- 英文名:3-O-Methyldopamine hydrochloride
- 中文名:甲醇中甲氧酩胺溶液标准物质
- CBNumber:CB00135530
- 分子式:C9H13NO2.ClH
- 分子量:203.67
- MOL File:1477-68-5.mol
- 熔点 :213-215 °C(lit.)
- 闪点 :9℃
- 储存条件 :-20°C
- 溶解度 :DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
- 形态 :crystalline
- 颜色 :white to light brown
- BRN :3631283
- 稳定性 :Stable, but may be light sensitive. Combustible. Incompatible with strong oxidizing agents.
- 危险品标志 :Xi
- 危险类别码 :36/37/38
- 安全说明 :26-36-37/39
- 危险品运输编号 :UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany :3
- F :3-10
- 危险等级 :IRRITANT
- 海关编码 :29222990
甲醇中甲氧酩胺溶液标准物质性质、用途与生产工艺
- 生物活性 3-Methoxytyramine (3-O-methyl Dopamine, 3MT) hydrochloride 是多巴胺的主要细胞外代谢产物,是一种神经调节剂,在某些情况下可能参与运动控制。
-
靶点
Human Endogenous Metabolite
-
体外研究
The intensity of the fluorescence developed is in a linear relation to the amount of 3-Methoxytyramine hydrochloride presented in the sample up to at least 1 μg. When a high concentration of dopamine is present in the reaction mixture, there is some reduction in the fluorescence derived from 3-Methoxytyramine hydrochloride.
-
体内研究
The extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity however, is mostly presented as a set of disorganized abnormal movements that includes tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 µg, at 9 µg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 µg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 µg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs.
- 用途 药物多巴胺的中间体。
- 用途 校准仪器和装置;评价方法;工作标准;质量保证/质量控制
- 生产方法 由2-甲氧基-4-(2-硝基乙烯)酚还原得到。将2-甲氧基-4-(2-硝基乙烯)酚、乙醇、水、锌粉及盐酸的混合物加热回流3h。冷却,静置过夜。过滤,滤液在10℃左右用碳酸钠中和至pH8-8.5。甩滤,滤液用正丁醇提取。提取液减压蒸馏回收丁醇后冷却,加氯化氢-甲醇回流半小时。冷却,结晶,过滤,滤饼用甲醇洗涤,80℃干燥,得3-O-甲基多巴胺盐酸盐。收率65-70%。
- 更新日期:2024/11/08
- 产品编号:17285
- 产品名称:2-甲氧基-4-(2-氨基乙基)苯酚 3-O-Methyldopamine hydrochloride, 99+%, Thermo Scientific Chemicals
- CAS编号:1477-68-5
- 包装:100mg
- 价格:958元
- 更新日期:2024/11/08
- 产品编号:17285
- 产品名称:2-甲氧基-4-(2-氨基乙基)苯酚 3-O-Methyldopamine hydrochloride, 99+%, Thermo Scientific Chemicals
- CAS编号:1477-68-5
- 包装:1g
- 价格:4577元
- 公司名称:UKRORGSYN-BB
- 联系电话:--
- 电子邮件:y.barysheva@ukrorgsynth.com
- 国家:乌克兰
- 产品数:6230
- 优势度:38