ChemicalBook CAS数据库列表 吉美嘧啶
吉美嘧啶
- CAS号:103766-25-2
- 英文名:Gimeracil
- 中文名:吉美嘧啶
- CBNumber:CB00125918
- 分子式:C5H4ClNO2
- 分子量:145.54
- MOL File:103766-25-2.mol
吉美嘧啶化学性质
- 熔点 :274 °C
- 沸点 :255.1±40.0 °C(Predicted)
- 密度 :1.56±0.1 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :Soluble in DMSO (up to 5 mg/ml).
- 形态 :solid
- 酸度系数(pKa) :4.50±1.00(Predicted)
- 颜色 :White
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey :ZPLQIPFOCGIIHV-UHFFFAOYSA-N
- CAS 数据库 :103766-25-2(CAS DataBase Reference)
安全信息
- 安全说明 :24/25
- 海关编码 :29337900
吉美嘧啶性质、用途与生产工艺
- 生物活性 Gimeracil是一种二氢脱氢酶的抑制剂，在双链断裂修复中，抑制早期同源重组。
-
靶点
Target Value Dihydropyrimidine dehydrogenase -
体外研究
Gimeracil reduces the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1.
Gimeracil may enhance the efficacy of radiotherapy through the suppression of HR-mediated DNA repair pathways.
Gimeracil pretreatment significantly restrains the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2.
Cell Viability Assay
Cell Line: DLD-1, HeLa, and LC-11 cell lines. Concentration: 1 mM. Incubation Time: 48 h. Result: Inhibits the repair of irradiation-induced DNA double strand breaks.
Did not increase the c-H2AX foci residual at 24 h in unirradiated cells.
-
体内研究
Gimeracil (2.5-25 mg/kg, orally) may inhibit the rapid repair of X-ray-induced DNA damage in tumors.
Animal Model: Nude mice (Lu-99, LC-11, KB/C3 and PAN-4 tumors were xenografted).
Dosage: 2.5-25 mg/kg. Administration: Orally. Result: Exhibited anti-tumor activity. - 用途 抗癌药S-1组成成分之一，可抑制抗肿瘤药物替加氟的毒副作用
吉美嘧啶上下游产品信息
上游原料
下游产品
吉美嘧啶 试剂级价格
- 更新日期：2024/11/11
- 产品编号：XW1037662523
- 产品名称：吉莫斯特 gimeracil;5-chloro-4-hydroxy-2(1h)-pyridinone;5-chloropyridine-2,4-diol;5-chloro-2,4-pyridinediol;5-chloro-2,4-dihydroxypyridine
- CAS编号：103766-25-2
- 包装：25G
- 价格：135元
- 更新日期：2024/11/11
- 产品编号：XW1037662522
- 产品名称：吉莫斯特 gimeracil;5-chloro-4-hydroxy-2(1h)-pyridinone;5-chloropyridine-2,4-diol;5-chloro-2,4-pyridinediol;5-chloro-2,4-dihydroxypyridine
- CAS编号：103766-25-2
- 包装：5G
- 价格：35元
吉美嘧啶生产厂家
- 公司名称：CHEMOS GmbH & Co. KG
- 联系电话：--
- 电子邮件：chemos@chemos.de
- 国家：德国
- 产品数：6727
- 优势度：58
103766-25-2, 吉美嘧啶相关搜索:
