99390-76-8

BMY-27709 is an inhibitor of influenza virus growth. BMY-27709 has an IC50 of 3-8 microM for A/WS33 virus growth in a multicycle replication assay and is active against all H1 and H2 subtype viruses tested. However, BMY-27709 was found to be inactive against H3 subtype viruses, as well as influenza B/Lee/40 virus. BMY-27709 was also found to act against H1 and H2 viruses early in infection, suggesting that the target for inhibition is the hemagglutinin protein.

BMY-27709 是一种流感病毒生长抑制剂，对 A/WSN/33 病毒生长的 IC50 值为 3-8 μM，对流感病毒的部分亚型也展现出抑制活性。BMY-27709 对 H1 和 H2 病毒感染的早期起作用，通过抑制血凝素蛋白展现其抗病毒活性。然而，BMY-27709 对 H3 亚型病毒以及 B 型/Lee/40 流感病毒没有作用。