96487-37-5
基本信息
Nuvenzepine
11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one
6,11-Dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-
物理化学性质
| 沸点 | 522.3±50.0 °C(Predicted) |
| 密度 | 1.267±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 10.99±0.20(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
奴文西平价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-U00119 | 奴文西平 Nuvenzepine | 96487-37-5 | 1mg | 1800元 |
| 2025/02/08 | HY-U00119 | 奴文西平 Nuvenzepine | 96487-37-5 | 5mg | 4000元 |
| 2024/08/19 | HY-U00119 | 奴文西平 Nuvenzepine | 96487-37-5 | 10mg | 6800元 |
常见问题列表
mAChR
Nuvenzepine shows a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions on isolated ileal musculature and on longitudinal ileum dispersed cells. Nuvenzepine is almost equipotent to pirenzepine in competitively preventing bethanechol-induced gall-bladder contractions and it displays a four-fold higher potency than pirenzepine in blocking vagal-stimulated tracheal constrictions.
Intraduodenally administration of Nuvenzepine displays a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. On ileal motor activity, Nuvenzepine shows a potency 10 times greater than that of pirenzepine. Nuvenzepine is also active, unlike pirenzepine, on colonic stimulated motility. Furthermore, in conscious cats, Nuvenzepine inhibits pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine. Nuvenzepine has been found to be very active in inhibiting gastric acid secretion and intestinal hypermotility in rats, with very slight atropine-like side effects. The oral absorption rate is relatively slow, that the absolute bioavailability is 30 to 40%, that the elimination rate is slow and there is no accumulation in the body, and that there is very little metabolism.