94356-26-0
基本信息
曲札茋苷
白皮杉醇-3'-O-葡萄糖苷
反式-白皮杉醇-3-O-葡萄糖苷
白皮杉醇-3'-O-葡萄糖苷对照品
白皮杉醇-3'-O-葡萄糖苷标准品
曲札茋苷、白皮杉醇-3'-O-葡萄糖苷
Piceatannol 3'
Piceatannol 3-glycoside
Piceatannol 3'-O-glucoside
trans-Piceatannol 3-glucoside
Piceatannol 3'-O-beta-D-glucopyranoside
3,5,3',4'-trihydroxy-stilbene -3'-b-D-glucoside
β-D-Glucopyranoside, 5-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-2-hydroxyphenyl
(E)-1-(3,5-dihydroxyphenyl)-2-(3-hydroxy-4-O-β-D-glucopyranose phenyl)ethylene
物理化学性质
| 熔点 | >219°C (dec.) |
| 沸点 | 721.6±60.0 °C(Predicted) |
| 密度 | 1.593±0.06 g/cm3(Predicted) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | DMSO（轻微）、乙醇（轻微、超声处理）、甲醇（轻微） |
| 酸度系数(pKa) | 9.16±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至灰白色 |
曲札芪苷价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-N2237 | 曲札芪苷 Piceatannol 3'-O-glucoside | 94356-26-0 | 1mg | 700元 |
| 2025/02/08 | HY-N2237 | 曲札芪苷 Piceatannol 3'-O-glucoside | 94356-26-0 | 5 mg | 1650元 |
| 2025/02/08 | HY-N2237 | 曲札芪苷 Piceatannol 3'-O-glucoside | 94356-26-0 | 10 mg | 2500元 |
常见问题列表
NO synthase
IC50: 11.22 μM (Arginase I), 11.06 μM (Arginase II)
Piceatannol 3'-O-glucoside (Piceatannol-3'-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3'-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3'-O-glucoside significantly decreases arginase I activity (75±5% at 1 µM, 72±7% at 3 µM, 62±1% at 10 µM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 µM Piceatannol 3'-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3'-O-glucoside (from 0 to 120 µM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 µM for the liver lysate and 11.06 µM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3'-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3'-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 µM and IC 50 value is 69 µM.
In order to ascertain whether Piceatannol 3'-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3'-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3'-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3'-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD.