926319-75-7
中文名称
化合物 T27032
英文名称
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS
926319-75-7
分子式
C21H37N7O3
分子量
435.56
MOL 文件
926319-75-7.mol
结构式
基本信息
中文别名
化合物 T27032
英文别名
CK59
CK-59
CK 59
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
CK-59
CK 59
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
物理化学性质
| 密度 | 1.22±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 12.93±0.46(Predicted) |
应用领域
用途一
CK59 is calcium-calmodulin-dependent kinase II (CaMKII) inhibitor. CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only fivefold larger than the reported IC50 values for CaMKII inhibition. The inhibition due to CK59 was reversible; washout of the drug brought calcium levels back to control values upon depolarization.
常见问题列表
概述
Protein kinase inhibitor 8 (Compound CK59) 是一种钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂。通过抑制 CaMKII 的活性，Protein kinase inhibitor 8 可以减弱全氟辛烷磺酸 (PFOS) 诱导的细胞毒性，并缓解 PFOS 诱导的 GLT-1 表达下调，从而降低神经元损伤。Protein kinase inhibitor 8 可用于神经疾病领域研究。