891849-87-9
英文名称
ZK-Thiazolidinone
CAS
891849-87-9
分子式
C23H26F3N5O2S
分子量
493.55
MOL 文件
891849-87-9.mol
结构式
![891849-87-9 结构式](https://www.chemicalbook.com/CAS/20180808/GIF/891849-87-9.gif)
基本信息
英文别名
ZK-Thiazolidinone
应用领域
用途一
ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiazolidinone impairs centrosome maturation.