886992-99-0
基本信息
Ac-Gly-BoroPro?, >98%
Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-
物理化学性质
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| 溶解度 | DMSO : ≥ 50 mg/mL (233.61 mM) |
| 酸度系数(pKa) | 9.72±0.20(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
886992-99-0价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-101801 | 886992-99-0 Ac-Gly-BoroPro | 886992-99-0 | 1mg | 2115元 |
| 2024/08/19 | HY-101801 | 886992-99-0 Ac-Gly-BoroPro | 886992-99-0 | 5mg | 8100元 |
常见问题列表
Ki: 23 nM (FAP)
FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K i =377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K i values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.