87116-72-1
中文名称
替莫贝松
英文名称
Timobesone
CAS
87116-72-1
分子式
C22H29FO4S
分子量
408.531
MOL 文件
87116-72-1.mol
结构式
基本信息
中文别名
替莫贝松
英文别名
Timobesone
Timobesone [inn]
9-Fluoro-11β,17α-dihydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17-carbothioic acid S-methyl ester
Androsta-1,4-diene-17-carbothioic acid, 9-fluoro-11,17-dihydroxy-16-methyl-3-oxo-, S-methyl ester, (11β,16β,17α)-
Timobesone [inn]
9-Fluoro-11β,17α-dihydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17-carbothioic acid S-methyl ester
Androsta-1,4-diene-17-carbothioic acid, 9-fluoro-11,17-dihydroxy-16-methyl-3-oxo-, S-methyl ester, (11β,16β,17α)-
物理化学性质
| 沸点 | 553.0±50.0 °C(Predicted) |
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 12.13±0.70(Predicted) |
常见问题列表
生物活性
Timobesone是一种局部皮质类固醇，但从未上市。
体外研究
The increase in the solubility of Timobesone acetate in the micellar solutions is dependent on the type and concentration of surfactant. The solubilizing capacity of the surfactant micelles and the distribution coefficient of Timobesone acetate in aqueous micellar solutions are found to increase with increasing length of the hydrophobic fatty acid group.