85375-85-5
英文名称
SK&F 89976-A
CAS
85375-85-5
分子式
C22H25NO2
分子量
335.44
MOL 文件
85375-85-5.mol
结构式
基本信息
英文别名
SKF-89976
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid
1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid
应用领域
用途一
SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.