85136-71-6
中文名称
替尼索洛尔
英文名称
Tilisolol
CAS
85136-71-6
分子式
C17H24N2O3
分子量
304.38
MOL 文件
85136-71-6.mol
结构式
基本信息
中文别名
替利洛尔
替尼索洛尔
替尼索洛尔
英文别名
Tilisolol
Tilisolol USP/EP/BP
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2-methylisoquinolin-1-one
4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methylisoquinoline-1(2H)-one
(+-)-4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1(2H)-isoquinolinone
4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1,2-dihydroisoquinoline-1-one
4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyloxy]-2-methylisoquinolin-1(2H)-one
1(2H)-Isoquinolinone, 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-2-methyl-
1(2H)-Isoquinolinone, 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-2-methyl- (9CI)
Tilisolol USP/EP/BP
4-[3-(tert-butylamino)-2-hydroxypropoxy]-2-methylisoquinolin-1-one
4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methylisoquinoline-1(2H)-one
(+-)-4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1(2H)-isoquinolinone
4-(3-tert-Butylamino-2-hydroxypropoxy)-2-methyl-1,2-dihydroisoquinoline-1-one
4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyloxy]-2-methylisoquinolin-1(2H)-one
1(2H)-Isoquinolinone, 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-2-methyl-
1(2H)-Isoquinolinone, 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-2-methyl- (9CI)
所属类别
原料药：替尼类抗肿瘤药
制备方法
方法1
4-羟基-2-甲基-1(2H)-异喹啉酮和环氧氯丙烷，在甲醇钠的甲醇溶液中，于50～60℃反应，得化合物粗品。该粗品经柱层析提纯，得到的化合物与叔丁胺反应，可得替利洛尔。