848035-21-2
中文名称
Compound 48/80 (hydrochloride)
英文名称
Compound 48/80 (hydrochloride)
CAS
848035-21-2
分子式
C32H48Cl3N3O3
分子量
629.101
MOL 文件
848035-21-2.mol
结构式
物理化学性质
储存条件 | Store at -20°C, sealed storage, away from moisture ,protect from light |
溶解度 | Water: 100 mM |
形态 | 固体 |
颜色 | White to off-white |
常见问题列表
生物活性
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
体外研究
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80.
体内研究
Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter.
Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation.
Animal Model: | 7-week-old Wistar male rats (fasted for 24 hours) |
Dosage: | 0.75 mg/kg |
Administration: | Intraperitoneal injection; Killed after 0.5, 3 or 6 h |
Result: | Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter. |
供应商信息 更多
上海麦克林生化科技股份有限公司
联系电话:
15221275939 15221275939
产品介绍:
英文名称:Compound 48/80 hydrochloride
CAS:848035-21-2
纯度:98%
包装信息:10mg
ChemeGen 中国
联系电话:
18818260767
产品介绍:
英文名称:Compound 48/80 trihydrochloride
CAS:848035-21-2
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
天津普西唐生物医药科技有限公司
联系电话:
010-60605840 15801484223
产品介绍:
英文名称:Compound 48/80 trihydrochloride
CAS:848035-21-2
纯度:98%
包装信息:50mg
上海迈瑞尔生化科技有限公司
联系电话:
18621169109
产品介绍:
英文名称:Compound 48/80 hydrochloride
CAS:848035-21-2
纯度:98%
包装信息:10mg;50mg
备注:M64205
上海一飞生物科技有限公司
联系电话:
021-65675885 18964387627
产品介绍:
英文名称:Compound 48/80 (hydrochloride)
CAS:848035-21-2
纯度:95%
包装信息:5mg;100mg;1mL
备注:试剂级
銳迪國際科技有限公司
联系电话:
18024082417
产品介绍:
英文名称:Compound 48/80 trihydrochloride
CAS:848035-21-2
纯度:5mg;10mg;50mg;100mg;250mg;500mg;1g
包装信息:5mg;10mg;50mg;100mg;250mg;500mg;1g
上海甄准生物科技有限公司
联系电话:
15102117276 19921389125
产品介绍:
中文名称:复合物48/80三氯化氢
英文名称:Compound 48/80 trihydrochlorid
CAS:848035-21-2
纯度:0.95
包装信息:10mg;