84746-43-0
基本信息
小心脏活性肽B SCPB
MNYLAFPRM-NH2
SMALL CARDIOACTIVE PEPTIDE B
CARDIOACTIVE PEPTIDE B (SMALL)
Small Cardioactive Peptide B (SCPB)
SCPB Cardioactive Peptide B (sMall)
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE
H-MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
MET-ASN--LEU-ALA-PHE-PRO-ARG-MET (MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET AMIDE)
物理化学性质
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 9.82±0.15(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
安全数据
| WGK Germany | 3 |
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-P1495 | MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2 Small Cardioactive Peptide B (SCPB) | 84746-43-0 | 1mg | 700元 |
| 2024/08/19 | HY-P1495 | MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2 Small Cardioactive Peptide B (SCPB) | 84746-43-0 | 5mg | 1600元 |
| 2024/08/19 | HY-P1495 | MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2 Small Cardioactive Peptide B (SCPB) | 84746-43-0 | 10mg | 2300元 |
常见问题列表
EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)
Small cardioactive peptide B (SCP B ) is a neurally active peptide endogenous to Aplysia . Small cardioactive peptide B (SCP B ) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCP B ) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCP B ) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCP B ) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCP B ) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC 50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCP B ) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC 50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCP B )is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCP B ) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC 50 of 0.1 and 1.0μM, respectively.