基本信息 物理化学性质 常见问题列表 供应商 相关产品
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83656-38-6

中文名称 异丙地尔
英文名称 ipramidil
CAS 83656-38-6
分子式 C10H16N4O4
分子量 256.26
MOL 文件 83656-38-6.mol
结构式 83656-38-6 结构式

基本信息

中文别名 异丙地尔
英文别名 C80-1324
ipramidil
N,N'-Bis(1-methylethyl)furazan-3,4-dicarboxamide 2-oxide
3,4-Bis[(isopropylamino)carbonyl]-1,2,5-oxadiazole 2-oxide
1,2,5-Oxadiazole-3,4-dicarboxamide, N3,N4-bis(1-methylethyl)-, 2-oxide

物理化学性质

密度 1.38±0.1 g/cm3(Predicted)
储存条件 -20°C储存
溶解度 溶于二甲基亚砜
酸度系数(pKa) 11.92±0.46(Predicted)
形态 Solid
颜色 Off-white to light yellow

常见问题列表

生物活性
Ipramidil (C80-1324) 是一种呋咱环化合物。在离体心脏的冠脉循环中具有显著的扩张活性。
体外研究

The vasodilator action of Ipramidil (C80-1324) on coronary vessels is more potent than that of GTN and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by glyceryl trinitrate (GTN) is blunted upon coinfusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL,which induces an increase in coronary flow of 67±9% (N=5). Moreover, the vasodilatoreffect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance (P=0.493, N=3). However,when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished (P=0.006, N=3). Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect.

供应商信息 更多

TargetMol中国(陶术生物)
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产品介绍:
中文名称:异丙地尔
英文名称:Ipramidil
CAS:83656-38-6
纯度:98%
包装信息:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600