78499-27-1
中文名称
化合物 T14546
英文名称
bermoprofen
CAS
78499-27-1
分子式
C18H16O4
分子量
296.32
MOL 文件
78499-27-1.mol
结构式
基本信息
中文别名
化合物 T14546
英文别名
AD-1590
Brn 4815717
10,11-DIHYDRO-&alpha
-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID
2-(8-Methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)propionic
10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepine-2-acetic acid
Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)-
Brn 4815717
10,11-DIHYDRO-&alpha
-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID
2-(8-Methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)propionic
10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepine-2-acetic acid
Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)-
物理化学性质
| 熔点 | 128-129° |
| 沸点 | 397.92°C (rough estimate) |
| 密度 | 1.1874 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | -20°C储存 |
| 形态 | Solid |
| 颜色 | Off-white to light yellow |
安全数据
| 毒性 | LD50 in mice, rats (mg/kg): 500, 147 orally (Nakamura) |
常见问题列表
生物活性
Bermoprofen (AD-1590) 是一种具有口服活性地非甾体类抗炎药。Bermoprofen 具有有效的解热和镇痛作用，且生物半衰期短。Bermoprofen 是 LPS 诱导的兔发烧的有效拮抗剂。
体外研究
Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents.
体内研究
Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits.
| Animal Model: | Male albino rabbits, 2.3-3 kg |
| Dosage: | 0.04, 0.4, 0.1 mg/kg |
| Administration: | Oral; given 1 h after i.v. injection of LPS |
| Result: | Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg. |