77074-49-8
基本信息
甲状腺素硫酸
硫酸L-甲状腺素
L-甲状腺素硫酸盐
L-Thyroxine sulfate
Thyroxine 4'-O-Sulfate
L-Thyroxine sulfate salt
Thyroxine Hydrogen Sulfate
O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo L-tyrosine
L-Tyrosine, O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo-
物理化学性质
| 密度 | 2.658±0.06 g/cm3(Predicted) |
| 储存条件 | Store at 4°C |
| 溶解度 | DMSO : ≥ 31 mg/mL (36.18 mM) |
| 酸度系数(pKa) | -4.80±0.18(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
常见问题列表
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Human Endogenous Metabolite
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Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate.
Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels.