76123-41-6
中文名称
化合物 T32026
英文名称
GYKI 13324
CAS
76123-41-6
分子式
C10H18Cl2N6O6
分子量
389.19
MOL 文件
76123-41-6.mol
结构式
基本信息
中文别名
化合物 T32026
英文别名
GYKI 13324
1-(2-chloroethyl)-3-[4-[2-chloroethylcarbamoyl(nitroso)amino]-2,3-dihydroxybutyl]-1-nitrosourea
1-(2-chloroethyl)-3-[4-[2-chloroethylcarbamoyl(nitroso)amino]-2,3-dihydroxybutyl]-1-nitrosourea
应用领域
用途一
GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.