71861-76-2
中文名称
1-acetyl-3,2-toluyl-5-fluorouracil
英文名称
1-acetyl-3,2-toluyl-5-fluorouracil
CAS
71861-76-2
分子式
C14H11FN2O4
分子量
290.25
MOL 文件
71861-76-2.mol
结构式
基本信息
中文别名
化合物 T10013
英文别名
A-?OT-?Fu
1-Acetyl-3-o-toluyl-5-fluorouracil
1-acetyl-3,2-toluyl-5-fluorouracil
2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-
1-Acetyl-3-o-toluyl-5-fluorouracil
1-acetyl-3,2-toluyl-5-fluorouracil
2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-
物理化学性质
熔点 | 141-143 °C(Solv: ethyl ether (60-29-7)) |
沸点 | 408.8±55.0 °C(Predicted) |
密度 | 1.44±0.1 g/cm3(Predicted) |
储存条件 | -20°C储存 |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | -5.29±0.40(Predicted) |
常见问题列表
生物活性
1-Acetyl-3-o-toluyl-5-fluorouracil是有效的抗肿瘤剂。
体内研究
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).