685121-45-3
物理化学性质
| 沸点 | 416.6±45.0 °C(Predicted) |
| 密度 | 1.68±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO: 83.33 mg/mL (235.26 mM) |
| 酸度系数(pKa) | 1.72±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | White to yellow |
化合物SYNUCLEAN-D价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-124876 | 化合物SYNUCLEAN-D SynuClean-D | 685121-45-3 | 1 mg | 1400元 |
| 2026/09/15 | HY-124876 | 化合物SYNUCLEAN-D SynuClean-D | 685121-45-3 | 5mg | 3700元 |
| 2026/09/15 | HY-124876 | 化合物SYNUCLEAN-D SynuClean-D | 685121-45-3 | 10mM * 1mLin DMSO | 4070元 |
常见问题列表
SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity.
The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration.