682741-29-3
基本信息
HTS 01037 (HTS01037
4-{[2-(methoxycarbonyl)-5-(2-thinyl)-3-thienyl]amino}-4-oxo-2-butenoic acid
[2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-, 5-methyl ester
物理化学性质
| 储存条件 | RT |
| 溶解度 | 溶于 DMSO（高达 50 mg/ml） |
| 形态 | 固体 |
| 颜色 | 黄色 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 中的溶液可在 -20°C 下保存长达 2 个月。 |
化合物 T15506价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-101503 | 化合物 T15506 HTS01037 | 682741-29-3 | 5mg | 770元 |
| 2024/04/30 | HY-101503 | 化合物 T15506 HTS01037 | 682741-29-3 | 10mg | 1350元 |
| 2024/04/30 | HY-101503 | 化合物 T15506 HTS01037 | 682741-29-3 | 25mg | 2850元 |
常见问题列表
IC50: 0.67 μM (AFABP/aP2)
HTS01037 functions as a high affinity ligand of AFABP/aP2 with an apparent K i of 0.67 μM. HTS01037 is somewhat selective for AFABP/aP2, but at higher concentrations is a pan-specific FABP inhibitor. HTS01037 inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. HTS01037 acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophage or CV-1 cells. Treatment of microglial cells with HTS01037 increases expression of Ucp2 and arginase in the presence or absence of palmitic acid. Moreover, cells exposed to HTS01037 exhibits attenuated expression of inducible nitric oxide synthase (iNOS) compared to palmitic acid alone indicating reduced NFκB signaling. Treatment of macrophages with HTS01037results in a marked decrease in both basal and fatty acid-stimulated LTC4 secretion but no change in 5-HETE production or 5-lipoxygenase expression.