63345-17-5
中文名称
化合物 T32014
英文名称
1-Propanesulfonamide, 3-[ (aminoiminomethyl)amino]-N-[4-[(3-nitro-9-acridinyl)amino]pheny l]-, dihydrochloride
CAS
63345-17-5
分子式
C23H24ClN7O4S
分子量
530
MOL 文件
63345-17-5.mol
结构式
基本信息
中文别名
化合物 T32014
英文别名
GTC 365 hydrochloride
GTC 365 hydrochloride (NSC 177365)
1-Propanesulfonamide, 3-[ (aminoiminomethyl)amino]-N-[4-[(3-nitro-9-acridinyl)amino]pheny l]-, dihydrochloride
GTC 365 hydrochloride (NSC 177365)
1-Propanesulfonamide, 3-[ (aminoiminomethyl)amino]-N-[4-[(3-nitro-9-acridinyl)amino]pheny l]-, dihydrochloride
应用领域
用途一
GTC365 is a hTERT transcriptional repressor. GTC365 acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstate the correct folding pathway, and reduce hTERT activity through transcriptional repression.