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Orthosilicic acid is the form predominantly absorbed by humans and is found in numerous tissues including bone, tendons, aorta, liver and kidney. Persuasive data suggest that silica is essential for health although no RDI has been established. However, a deficiency of silica induces deformities in skull and peripheral bones, causes poorly formed joints, reduced contents of cartilage, collagen, and disruption of mineral balance in the femur and vertebrae.