5947-49-9
基本信息
PODOCARPIC ACID
Einecs 227-706-3
Podocarpic acid 98%
Podocarpic acid, >99%
12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID
Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (van) (8ci)
1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID
1,2,3,4,4a,9,10,10aβ-Octahydro-6-hydroxy-1,4aα-dimethyl-1α-phenanthrenecarboxylic acid
(1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid
物理化学性质
| 熔点 | 193-196 °C (lit.) |
| 比旋光度 | 20546 +165° (c = 4 in abs ethanol) |
| 沸点 | 449.6±45.0 °C(Predicted) |
| 密度 | 1.182±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C储存 |
| 溶解度 | DMSO: ≥ 100 mg/mL (364.50 mM) |
| 酸度系数(pKa) | 4.66±0.40(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
| 旋光度 (Optical Rotation) | [α]20/D +133°, c = 4 in ethanol |
| Merck | 13,7625 |
| InChI | 1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)/t14-,16-,17+/m1/s1 |
| InChIKey | VJILEYKNALCDDV-OIISXLGYSA-N |
| SMILES | [H][C@@]12CCc3ccc(O)cc3[C@@]1(C)CCC[C@]2(C)C(O)=O |
安全数据
| WGK Germany | 3 |
| 存储类别 | 11 - Combustible Solids |
罗汉松酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-N2318 | 罗汉松酸 Podocarpic acid | 5947-49-9 | 5 mg | 220元 |
| 2026/09/15 | HY-N2318 | 罗汉松酸 Podocarpic acid | 5947-49-9 | 10 mM * 1 mL in DMSO | 242元 |
| 2026/09/15 | HY-N2318 | 罗汉松酸 Podocarpic acid | 5947-49-9 | 10mg | 353元 |
常见问题列表
Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells.
Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca 2+ flux, which is significantly reduces when the Ca 2+ -impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels.