58456-91-0
中文名称
MK-447
英文名称
2-aminomethyl-4-t-butyl-6-iodophenol
CAS
58456-91-0
分子式
C11H16INO
分子量
305.16
MOL 文件
58456-91-0.mol
结构式
基本信息
中文别名
化合物 T12063
英文别名
MK-447
2-aminomethyl-4-t-butyl-6-iodophenol
2-(aminomethyl)-4-tert-butyl-6-iodophenol
6-Iodo-2-(aminomethyl)-4-tert-butylphenol
Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo-
2-aminomethyl-4-t-butyl-6-iodophenol
2-(aminomethyl)-4-tert-butyl-6-iodophenol
6-Iodo-2-(aminomethyl)-4-tert-butylphenol
Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo-
物理化学性质
熔点 | 146-146.5 °C (decomp) |
沸点 | 306.9±42.0 °C(Predicted) |
密度 | 1.552±0.06 g/cm3(Predicted) |
储存条件 | -20°C储存 |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 7.30±0.50(Predicted) |
常见问题列表
生物活性
MK-447 是一种自由基清除剂,同时为非甾体类抗炎剂,能够增强 PGH2 等其他前列腺素 (prostaglandin) 的形成。
靶点
PGH 2
|
PGI 2
|
体外研究
MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG 2 and also enhances the formation of the endoperoxide, PGH 2 , and other prostaglandins. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta.
体内研究
MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs.