基本信息 物理化学性质 螺莫司汀价格(试剂级) 常见问题列表 供应商 相关产品
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56605-16-4

中文名称 螺莫司汀
英文名称 Spiromustine
CAS 56605-16-4
分子式 C14H23Cl2N3O2
分子量 336.26
MOL 文件 56605-16-4.mol
结构式 56605-16-4 结构式

基本信息

中文别名 螺莫司汀
英文别名 SHM
NCI172112
NSC268497
NSC-172112
Spiromustine
Spiromustard
spirohydantoin mustard
Spirohydantoin masturd
Spiromustine USP/EP/BP
3-[2-[Bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione
所属类别 原料药:烷化剂类抗肿瘤药

物理化学性质

熔点 125.5°C
密度 1.3876 (rough estimate)
折射率 1.6070 (estimate)
储存条件 -20°C储存
溶解度 溶于二甲基亚砜
酸度系数(pKa) 10.53±0.20(Predicted)
形态 Solid
颜色 White to off-white

常见问题列表

生物活性
NCI172112 是一种经典的双功能烷化剂,是为了开发有效抗中枢神经系统肿瘤而合成的一种抗肿瘤剂。
体内研究

NCI172112 (Spirohydantoin mustard, SHM) might serve as a carrier to cross the blood brain barrier. The cumulative excretion of radioactivity in the urine and faeces of rats after administration of [2-chloroethyl-U- 14 C]NCI172112 or [hydantoin-4- 14 C]NCI172112 ( 3.13 mg/kg. i.v.) is measured. Four hours after dosing, a significantly (P<0.005) greater amount of radioactivity has been excreted in the urine of rats treated with [hydantoin- 14 C]NCI172112 than with [ethyl- 14 C]NCI172112. However, by 24 h, approx.50% of dose is recovered in the urine with both labelled materials. Clearance of radioactivity in the faeces is slow, but, as for the renal excretion, is significantly greater for the hydantoin- 14 C moiety. No radioactivity is found in the expired air of a rat receiving a single dosing of [hydantoin- 14 C]NCI172112 and less than 1% is measured after administration of [ethyl- 14 C]NCI172112. Renal clearance of radioactivity is similar 4 h after administration of [ 14 C]NCI172112 to rats with biliary cannulas, with 14.1±2.9 and 17.5±2.1% of the ethyl- 14 C and 34.5±2.5 and 33.1±6.3%, of the hydantoin- 14 C dose appearing in the urine after dosing with 3.13 and 6.25 mg/kg, respectively. A difference in the 4 h urinary excretion of the two labels also is observed in dogs given [ 14 C]NCI172112 (1 mg/kg, i.v.). The percentages of hydantoin- 14 C and ethyl- 14 C eliminated are 29.4±2.7% and 17.2±3.5%, respectively (P<0.05).

供应商信息 更多

江阴康源生物医药科技有限公司
联系电话: 0510-86010668
产品介绍:
CAS:56605-16-4
包装信息:1g m
天津普西唐生物医药科技有限公司
联系电话: 010-60605840 15801484223
产品介绍:
英文名称:NCI172112
CAS:56605-16-4
纯度:98%
包装信息:1mg
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 NCI172112
英文名称:NCI172112
CAS:56605-16-4
包装信息:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
上海陌孚医药科技有限公司
联系电话: 021-59167510 18117107507
产品介绍:
英文名称:NCI172112
CAS:56605-16-4
纯度:>=99%
包装信息:10mg;1mg;50mg;5mg;100mg

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