50656-68-3
中文名称
化合物 T24883
英文名称
tingenin B
CAS
50656-68-3
分子式
C28H36O4
分子量
436.58
MOL 文件
50656-68-3.mol
结构式
基本信息
中文别名
化合物 T24883
英文别名
tingenin B
22β-Hydroxymaytenin
22β-Hydroxytingenone
3,22β-Dihydroxy-24,29-dinorfriedela-1(10),3,5,7-tetrene-2,21-dione
3,22β-Dihydroxy-24,29-dinor-D:A-friedoolean-1(10),3,5,7-tetrene-2,21-dione
24,25,26,30-Tetranoroleana-1(10),3,5,7-tetraene-2,21-dione, 3,22-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20β,22β)-
22β-Hydroxymaytenin
22β-Hydroxytingenone
3,22β-Dihydroxy-24,29-dinorfriedela-1(10),3,5,7-tetrene-2,21-dione
3,22β-Dihydroxy-24,29-dinor-D:A-friedoolean-1(10),3,5,7-tetrene-2,21-dione
24,25,26,30-Tetranoroleana-1(10),3,5,7-tetraene-2,21-dione, 3,22-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20β,22β)-
应用领域
用途一
Tingenin B, the plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. This compounds target cancer stem cells (CSCs), Tingenin b was cytotoxic against MCF-7s (IC50 value for 48 h was found to be 2.38 μM) by inducing apoptosis. It was evident by Annexin V staining positivity, decreased mitochondrial membrane potential and Bcl-2 dephosphorylation with a concomitant increase in Bax protein expression. In addition, endoplasmic reticulum stress was also found to be involved in tingenin b-induced cell death.