478908-51-9
英文名称
GGTI-2166
CAS
478908-51-9
分子式
C25H30N4O3
分子量
434.53
MOL 文件
478908-51-9.mol
结构式
基本信息
英文别名
GGTI-2166
L-Leucine, N-[[5-[(1H-imidazol-5-ylmethyl)amino]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
L-Leucine, N-[[5-[(1H-imidazol-5-ylmethyl)amino]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
应用领域
用途一
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.