4757-55-5
基本信息
dimethacrine
10(9H)-AcridinepropanaMine,N,N,9,9-tetraMethyl-
9,9-Dimethyl-10-[3-(dimethylamino)propyl]acridan
3-(9,9-dimethylacridin-10-yl)propyl-dimethyl-amine
3-(9,9-dimethylacridin-10-yl)-N,N-dimethylpropan-1-amine
3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
9,10-Dihydro-9,9-dimethyl-10-(3-dimethylaminopropyl)acridine
物理化学性质
| 沸点 | bp1 200° |
| 密度 | 0.9927 (rough estimate) |
| 折射率 | 1.5640 (estimate) |
| 储存条件 | -20°C储存 |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.49±0.28(Predicted) |
常见问题列表
Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. Dimetacrine in the highest concentration, 10 μM, decreases the contractile force to 36.5±9.1%. Dimetacrine, 0.3 μM, causes no statistically significant decline in contractile force from the controls. Tachycardia is observed after the administration of Dimetacrine, 1 to 3 mg/kg i.v., and the maximum response is obtained in dose of 3 mg/kg i.v.. The administration of Dimetacrine, 30 mg/kg i.v., causes an abrupt fall in blood pressure with tachycardia or bradycardia followed by cardiac arrest. Respiratory rate increases 40 min after the onset of infusion of Dimetacrine. Arterial blood pressure falls 50 min after the onset of infusion of Dimetacrine.