317326-90-2
中文名称
HLI 98C; HL98C
英文名称
HLI 98C
CAS
317326-90-2
分子式
C17H9ClN4O4
分子量
368.73
MOL 文件
317326-90-2.mol
结构式
基本信息
中文别名
化合物 T27546
英文别名
HL98C
HLI 98C
HLI 98C
HL98C
10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
HLI 98C
HLI 98C
HL98C
10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
物理化学性质
| 熔点 | 368-369 °C(Solv: water (7732-18-5)) |
| 密度 | 1.66±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.71±0.20(Predicted) |
应用领域
用途一
HLI98C is a HDM2 ubiquitin ligase inhibitor. HLI98C exhibits cytotoxic activities and HDM2 E3 ligase inhibitory activities. In cells, HLI98C allows the stabilization of p53 and HDM2 and activation of p53-dependent transcription and apoptosis. The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. HLI98C may demonstrate anti-tumor activity by inhibiting recognition of the E3 enzyme and substrate.
常见问题列表
概述
HLI98C 是一种泛素连接酶抑制剂。HLI98C 抑制 p53 泛素化。HLI98C 抑制 HDM2 自泛素化。