314022-97-4
中文名称
化合物 T26585
英文名称
AK 301
CAS
314022-97-4
分子式
C19H21ClN2O2
分子量
344.84
MOL 文件
314022-97-4.mol
结构式
![314022-97-4 结构式](https://www.chemicalbook.com/CAS/20211123/GIF/314022-97-4.gif)
应用领域
用途一
AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release. This apoptotic response was significantly higher for AK301 than for other mitotic inhibitors tested (colchicine, vincristine, and BI 2536).