207556-62-5
CAS
207556-62-5
分子式
C15H20Cl2N6O
分子量
371.265
MOL 文件
207556-62-5.mol
结构式
![207556-62-5 结构式](https://www.chemicalbook.com/CAS/20180906/GIF/207556-62-5.gif)
常见问题列表
生物活性
NVP-DPP728 dihydrochloride 是一种高效、选择性的二肽基肽酶 IV (DPP-IV) 抑制剂,其 Ki 为 11 nM。NVP-DPP728 dihydrochloride 可用于糖尿病的研究。
靶点
Ki: 11 nM (DPP-IV)
体外研究
NVPDPP728 inhibits human and rat plasma DPP-IV (IC
50
s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
体内研究
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.
Animal Model: | Obese (fa/fa) and lean (FA/?) Zucker rats |
Dosage: | 3.72 mg/kg |
Administration: | Oral administration |
Result: | Led to inhibition of plasma DPP-IV activity. |